Transformative Advances in Biotherapeutic Analysis and Methods

In 2025, the PEGS Analytical Stream will showcase the latest advancements in biotherapeutic analysis across three dynamic tracks. The ML and Digital Integration in Biotherapeutic Analytics track will explore how digital tools and AI are transforming data integration, validation, and analysis across discovery, development, and clinical stages. The Biophysical Methods track will highlight innovations in automation, microfluidics, and emerging technologies, addressing challenges in characterizing novel modalities with legacy methods. Finally, the Characterization for Novel Biotherapeutics track will delve into the complexities of co-formulations, BBB-crossing therapies, and genetic medicines, alongside advancements in multispecifics, conjugations, and oligonucleotide therapeutics. Together, these tracks offer a comprehensive view of cutting-edge analytical methods shaping the future of biotherapeutic research and development.

Conferences Include:

May 12-13

ML and Digital Integration in Biotherapeutic Analytics

May 13-14

Biophysical Methods

May 15-16

Characterization for Novel Biotherapeutics

Keynote and Featured Speakers:

AI in Biopharmaceutical Development: What Could Go Wrong?
Christopher P. Calderon, PhD, Associate Research Professor, Chemical and Biological Engineering, University of Colorado

Complete Sequencing of Large Modified Peptide-Nucleic Acids Using MALDI TOF MS/MS
Igor A. Kaltashov, PhD, Professor, Chemistry, University of Massachusetts, Amherst

Analytical Development Challenges for a Diverse Product Portfolio
Ivan R. Correia, PhD, Senior Research Fellow & Head, Global Protein Sciences, AbbVie, Inc.

2025 PROGRAMS

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• Display of Biologics
• Engineering Antibodies
• Machine Learning for Protein Engineering

• Antibodies for Cancer Therapy
• Emerging Targets for Oncology & Beyond
• Driving Clinical Success in Antibody-Drug Conjugates

• TS: Intro to Multispecific Antibodies
• Advancing Multispecific Antibodies
• Engineering Bispecific and Multifunctional Antibodies

• Advances in Immunotherapy
• Engineering Cell Therapies
• Next-Generation Immunotherapies

• Difficult-to-Express Proteins
• Optimizing Protein Expression
• Maximizing Protein Production Workflows

• ML and Digital Integration in Biotherapeutic Analytics
• Biophysical Methods
• Characterization for Novel Biotherapeutics

• TS: Intro to Immunogenicity
• Predicting Immunogenicity with AI/ML Tools
• TS: Bioassay Development and Analysis

• Biologics for Immunology Indications
• Radiopharmaceutical Therapies
• Next-Generation Immunotherapies

• ML and Digital Integration in Biotherapeutic Analytics
• Predicting Immunogenicity with AI/ML Tools
• Machine Learning for Protein Engineering