Tools and Winning Strategies for Creating the Next Generation of Biologics
Antibody engineers are overcoming hurdles in creating the next generation of antibodies and biologics. Current challenges include generating binders against immune blockers, designing ligands to combat HIV and other infectious diseases, using high throughput and molecular design approaches to improve the pace and quality of antibody discovery and enabling delivery across the blood-brain barrier for CNS applications. The versatility of phage and yeast display, coupled with vast improvements in antibody engineering and production, are expanding the realm of possibilities for creating multi-domain therapeutic entities and improving the success rate of novel constructs.
Phage and Yeast Display of Antibodies
Engineering Antibodies
Engineering Bispecific Antibodies