In silico Immunogenicity Predictions
Sunday, April 30, 2017
2:00 PM - 5:00 PM
In-silico Immunogenicity Predictions (Hands-on) Workshop*
Instructors: Vinodh B. Kurella, Ph.D., Ph.D., Senior Scientist, Molecular Engineering Unit, Intexon Corp.
Paolo Marcatili, Ph.D., Asst. Professor, Bio and Health Informatics Department, Technical University of Denmark
Computational immunogenicity predictions for antibodies as well as pathogens help in the rational design and re-engineering. This facilitates to minimize anti-drug antibodies (ADA) as well as better vaccine design. Latest in-silico tools can shorten the process from design to preclinical validations.
The following topics will be covered:
- Computational prediction for T cell and B cell epitopes from primary sequences
- Antigen structure prediction via protein homology model
- Structure or homology model based Vaccine/antigen design
- Structural differences between MHC-I and MHC-II binding
- MHC class I and MHC class II predictions from peptide sequences
- Overview on the latest immunogenicity prediction programs
*All materials, including tutorials/exercises, will be available for users during and after the workshop. No prior programming experience necessary. Please bring your laptop for the workshop.